Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics
نویسندگان
چکیده
منابع مشابه
Genetics of Type 2 Diabetes- A Review Article
Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common forms of disease. By designing Genome Wi...
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OBJECTIVE Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A(1c) (HbA(1c)) target of <7% in people with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted an electronic search for randomized controlled trials (RCTs) involving insulin ...
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In this Perspective, Jose Florez discusses how information from genetics and genomics may be able to contribute to prevention of type 2 diabetes and predicting individual responses to behavioral and other interventions.
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Laboratory measurements of hemoglobin A1c above 6.5% were approved as an additional diagnostic criteria for diabetes mellitus by the American Diabetes Association in 2010. Several recent pediatric studies have cast HbA1c measurement in children in an unfavorable light in the pediatric population, by comparing HbA1c measurements to results on oral glucose tolerance test (OGTT) or fasting plasma ...
متن کاملUse of hemoglobin A1C to detect Haitian-Americans with undiagnosed Type 2 diabetes.
OBJECTIVE To evaluate the validity of hemoglobin A1C (A1C) as a diagnostic tool for type 2 diabetes and to determine the most appropriate A1C cutoff point for diagnosis in a sample of Haitian-Americans. SUBJECTS AND METHODS Subjects (n = 128) were recruited from Miami-Dade and Broward counties, FL. Receiver operating characteristics (ROC) analysis was run in order to measure sensitivity and s...
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ژورنال
عنوان ژورنال: The Review of Diabetic Studies
سال: 2015
ISSN: 1613-6071,1614-0575
DOI: 10.1900/rds.2015.12.351